Capillary ElectrophoresisHealthcare 

Capillary Electrophoresis and its Applications in Healthcare Sector

The term ‘Capillary Electrophoresis (CE)’ is made from two different words capillary and electrophoresis. The word ‘capillary’ refers to a narrow glass tube similar to a narrow tunnel, and ‘electrophoresis’ refers to a technique that separates the ions as per their sizes using different electric current levels.

The use of Capillary Electrophoresis (CE) in the healthcare sector is constantly increasing due to its capabilities of analyzing several proteins such as ribonucleic acid (RNA) and deoxyribonucleic acid (DNA).

This article will highlight the in-depth information on CE and its current market scenario.

Capillary Electrophoresis: An Overview

CE is used for treating several diseases such as pheochromocytoma, urinary stone, and pheochromocytoma, requiring advanced diagnostic methods.

CE procedures are also quite successful in identifying diseases and drug markers when used with spectrometric detection.

Capillary Electrophoresis
Capillary Electrophoresis

The CE is divided into several operational techniques primarily used to analyze and separate ions according to their provided mobility rate under applied electric currents.

The mobility rate of each ion varies from one another based on their atomic radius, molecular charge, and viscosity. Therefore, whenever specific electric currents are applied over ions, they move differently.

The complete CE procedure is done using a glass tube containing electrolyte solutions. Later, this tube is filled with a matrix of electrolytes and capillaries, and the sample ions are introduced into the same tube. As soon as the electric current is passed into the tube, the ions start moving in the opposite directions with respect to the moving direction of the electric chemical reactions.

At the end of the procedure, the experts get accurate data on the ions inside the tube with the help of a device called a detector.

The tube used in the CE procedure is made of uncoated or coated silica. Capillary zone electrophoresis and capillary gel electrophoresis are commonly used techniques to separate ions based on the CE procedure and the instruments used.

Capillary Zone Electrophoresis

This separation technique separates and analyzes macromolecules, nucleic acids, proteins, and separate peptides in the human body.

However, the primary thing that makes capillary gel electrophoresis (CGE) different from capillary zone electrophoresis (CZE) is separating blood samples with cations and inorganic anions.

Properties of CZE, such as electrophoretic mobility and electroosmotic mobility, are the main reasons for choosing this method to separate inorganic ions.

Working of Capillary Electrophoresis
Working of CE

Capillary Gel Electrophoresis

 Capillary gel electrophoresis (CGE) is a separation approach based on the electrophoresis principle.

This approach is mainly used to separate the charged molecules in the tube by filling it with gel fluid.

There are generally two gels used, namely physical gels and chemical gels. The type of gel fluid to be used in the capillary gel electrophoresis depends on the nature of the ions (organic or inorganic) that need to be separated.

The CGE technique is primarily used to separate and analyze macro or large molecules such as RNA, protein, and DNA.

 Industry Insight of Capillary Electrophoresis (CE) Market

CE has various applications such as software, consumables, viral load estimation, diagnosis of cancer, and analyzing nucleic acid and different protein sequences in various areas of the healthcare sector

Due to its several applications, the demand for global capillary electrophoresis is constantly increasing, and the market is expected to witness high growth in the coming years.

North America has the highest CE adoption rate, which is supposed to make this region dominate the global market during the forecast period 2021-2031.

The key factors boosting the market growth are strategic initiatives by the key market players, the rising adoption rate of gene sequencing techniques, and the increasing adoption of personalized medicines.

As per the BIS research, the global capillary electrophoresis market is anticiapted to grow from a market value of $338.4 million in 2021 to $586.9 million by 2031, with a CAGR of 5.66% during the forecasted period.

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Use of Capillary Electrophoresis (CE)

The CE techniques are mostly used in micro and nanofluids to detect and separate several ionic species from each other quickly.

Similarly, this technique is also used for identifying several types of biological molecules and organic compounds such as proteins and nucleic acids with the help of an electrophoresis instrument.

There are several applications of CE in daily life. Following are some of its applications:

  • The CE technique is in high demand in the pharmaceutical sector as a separation method due to its time efficiency and cost effectiveness.
  • The CE technique is widely used in diagnostic analysis and clinical sciences.
  • The CE technique can also be used for forensic testing such as blood sample testing, genetic testing, and capillary electrophoresis DNA.

The key reason behind the CE technique getting popular so rapidly compared to several other separation methods is that it requires only a few blood samples. Moreover, the process is automated and simple to perform.

Conclusion

Capillary Electrophoresis (CE) has some promising capabilities that the healthcare sector can use to alter the way of treatment selections for various diseases. This technology can help experts analyze several conditions more accurately to provide better treatment solutions for patients.

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